A study on parent’s perception towards children viewing cartoon channels

Television has become a member of every Indian family. Most of the children are eagerly watching cartoon programs on television. This is a subject of research that how television educates the children about various aspect of life and what are the impacts of cartoon programs on children. This study is used to know about children’s interest on type of cartoon and favourite channels and analyzing the parental perception towards children viewing cartoon.  This research indicates the positive and negative attitude of rural children towards various aspects of cartoon programs

FORMULATION AND NUTRIENT ANALYSIS OF STEVIA (STEVIA REBAUDIANA) INCORPORATED VALUE ADDED PRODUCTS

Objectives: To incorporate the stevia in the value added products like jam, Ice cream and chocolates and conduct organoleptic evaluation of the stevia incorporated value added products and to analyse the nutrient contents of the stevia incorporated prepared items. To create awareness of the beneficial effects of the Stevia to the diabetic patients. Methods: This study we incorporated the stevia in many value added products like chocolate, ice cream, cake, jam and milk shake. The Organoleptic evaluation was conducted and the results were tabulated. The nutrients like energy, protein, fat, calcium, phosphorous, iron, carbohydrate, dietary fibre, Vitamin C were analyzed using standard methods. The Physico-chemical constituents like moisture, ash, acid insoluble ash, and total sugar were analyzed using standard methods. The mean and standard deviation was used for the statistical analysis. Results: The sensory evaluation of Stevia incorporated mixed fruit jam and chocolate got less marks when compared to the control sample. Stevia incorporated chocolate cake got maximum marks when compared to the control sample. The energy and the carbohydrate was very low for the stevia incorporated mixed fruit jam, Chocolate Cake, Chocolate and Chocolate Ice Cream when compared to the control sample. Protein and fat of Stevia incorporated mixed fruit jam. Chocolate Cake, Chocolate and Chocolate Ice Cream have maximum value when compared to the control. Conclusion: It is very useful to prepare many sweets for the diabetic patients with the incorporation of stevia. The supplementation and evaluation of blood glucose levels for diabetic patients will be used to generate new views in future research. So as a nutritionist, we have to create the awareness about the benefits of Stevia to the community

DEVELOPMENT AND VALIDATION OF HIGH-PERFORMANCE LIQUID CHROMATOGRAPHIC METHOD FOR DETERMINATION OF DAPAGLIFLOZIN AND ITS IMPURITIES IN TABLET DOSAGE FORM

Objective: The aim of the present work is the development of new, sensitive, specific, and accurate high-performance liquid chromatographic method for the separation and determination of dapagliflozin and its impurities in tablet dosage form. Methods: The chromatographic separation of drug and its impurities was achieved using Hypersil BDS C18 column (250 mm × 4.6 mm, 5 μ) with mobile phase consisted of mobile phase-A (Buffer pH 6.5) and mobile phase-B (acetonitrile:water 90:10) by gradient program at a flow rate of 1 mL/min with ultraviolet detection at 245 nm. Results: Dapagliflozin and its impurities A, B, C, D, E, and impurity-F were successfully eluted at the retention time of 16.95, 2.72, 7.82, 10.58, 21.11, 30.37, and 34.36 min, respectively, with good resolution. The method was validated according to the international conference on harmonization guidelines. The validation results showed good precision, accuracy, linearity, specificity, sensitivity, and robustness. Conclusion: Successful separation and determination of dapagliflozin and its six impurities were achieved by the proposed method. The developed method can be applied for the routine analysis of dapagliflozin and its impurities in pharmaceutical formulations

Role of Type I IFNs in the in Vitro Attenuation of Live, Temperature-Sensitive Vaccine Strains of Human Respiratory Syncytial Virus

AbstractThe contributions of type I interferons (IFNs) to the in vitro attenuation of three temperature-sensitive (Ts) subgroup A and one subgroup B deletion mutant RSV strains were evaluated. The ability of these vaccine viruses to induce IFNs at their permissive and restrictive temperatures and their sensitivity to the antiviral effects of exogenous I IFNs were tested in human lung epithelial A549 cells. Our results show that the highly attenuated and immunogenic subgroup A vaccine strain Ts1C produced higher levels of IFN-β than its parent RSS-2 or two related strains, Ts1A and Ts1B, at their permissive temperature. Growth of RSV-infected A549 cultures at restrictive temperatures or prior UV inactivation of the virus abolished the observed induction of IFN-β, suggesting a strict requirement of viral replication for cellular IFN induction. The enhanced induction of IFN-β by the highly immunogenic Ts1C at permissive temperature may be an advantageous characteristic of a live intranasal vaccine candidate. The subgroup B strain RSV B1 and its mutant cp-52 (with SH and G gene deletions) both induced similar but low levels of IFN-β. Hence the observed overattenuation of cp-52 in human infants is probably not due to enhanced IFN induction during its replication in the host. The ability of cp-52, which does not express the SH and G proteins, to induce IFN-β levels similar to those of its parent strain suggests that these viral proteins may not have a role in the induction of IFN-β in the host. In addition, both subgroup A and B mutants and their respective parent strains were similarly resistant to the antiviral effects of exogenous IFN-α or -β. Therefore, increased sensitivity of the mutants to IFNs does not seem to contribute to their attenuation

Micropropagation of Dysophylla myosuroides (Roth.) Benth. In. Wall. through leaf culture

A method was developed through leaf as explant of Dysophylla myosuroides (Roth.) Benth. for multiple shoot regeneration. The effect of Auxins (IAA, NAA, IBA) and Cytokinins (BA) were studied on shoot regeneration in clulture. On MS half strength medium light green compact calli were formed with 0.1 mg l-1 NAA. The cultures produced 62.57 + 0.04 shoots on half strength medium with 0.5 mg l-1 BA and 0.01 mg l-1 NAA and also maximum mean length (0.52 + 0.02) of shoots were achieved. In vitro produced shoots rooted on half strength MS medium with 1 mg l-1 IBA. The in vitro regenerated plantlets were successfully acclimatized in paper cups containing vermiculate, then transferred to green house. Hardened plants were transplanted in to sand and soil (1 : 1)

In vitro cytokine response to tuberculosis

The outcome of any infectious disease is mainly dependent upon the interplay of the cytokines. These cytokines are grouped into two: Type land Type 2 cytokines secreted by Th1 and Th2 cells that contribute to the pro-inflammatory and anti-inflammatory responses respectively

A transform of complementary aspects with applications to entropic uncertainty relations

Even though mutually unbiased bases and entropic uncertainty relations play an important role in quantum cryptographic protocols they remain ill understood. Here, we construct special sets of up to 2n+1 mutually unbiased bases (MUBs) in dimension d=2^n which have particularly beautiful symmetry properties derived from the Clifford algebra. More precisely, we show that there exists a unitary transformation that cyclically permutes such bases. This unitary can be understood as a generalization of the Fourier transform, which exchanges two MUBs, to multiple complementary aspects. We proceed to prove a lower bound for min-entropic entropic uncertainty relations for any set of MUBs, and show that symmetry plays a central role in obtaining tight bounds. For example, we obtain for the first time a tight bound for four MUBs in dimension d=4, which is attained by an eigenstate of our complementarity transform. Finally, we discuss the relation to other symmetries obtained by transformations in discrete phase space, and note that the extrema of discrete Wigner functions are directly related to min-entropic uncertainty relations for MUBs.Comment: 16 pages, 2 figures, v2: published version, clarified ref [30

Analysis of suitable converter for the implementation of drive system in solar photovoltaic panels

Introduction. Photovoltaic (PV) systems gained immense attraction in the recent years since it produces electricity without causing environmental pollution through direct conversion of solar irradiance into electricity. Solar PV panels produce DC power. The magnitude of this DC power varies with temperature and irradiance of the sun rays. The DC supply from solar panels can be regulated using DC-DC converter and then can further be converted into the desired AC voltage by means of a voltage source inverter before being fed to an induction motor (IM). The speed and torque of an IM, fed from PV arrays, can vary due to the variation in the output power of the panels. Goal of this work is to improve the dynamic performance and reduce the torque ripple of Cuk converter-inverter fed IM drive system. The novelty of the current work proposes interleaved Cuk converter between solar PV DC source and the inverter. Purpose. To provide continuous current using an interleaved Cuk converter to the IM drive and in turn to reduce the torque ripple in IM. Methodology. Introduced an interleaved Cuk converter which is a blend of Cuk converters connected in parallel with each other between solar PV arrays and IM drive system. Originality. Simulation results are obtained for Cuk converter and interleaved Cuk converter fed IM drive by means of MATLAB. The hardware setup for the same IM systems is developed. Practical value. Simulation and hardware results are coincided with each other and it is subject from the simulation and hardware results that the interleaved Cuk converter-inverter fed IM system produced results superior than the Cuk converter inverter fed IM drive system.Вступ. Фотоелектричні (ФЕ) системи набули величезної привабливості в останні роки, оскільки вони виробляють електроенергію, не викликаючи забруднення навколишнього середовища, за рахунок прямого перетворення сонячного випромінювання на електрику. Сонячні ФЕ панелі виробляють енергію постійного струму. Значення цієї потужності постійного струму залежить від температури та освітленості сонячних променів. Подача постійного струму від сонячних панелей може регулюватися за допомогою DC-DC перетворювача, а потім може бути перетворена в бажану змінну напругу за допомогою інвертора джерела напруги перед подачею на асинхронний двигун. Швидкість та обертаючий момент асинхронного двигуна, що живиться від ФЕ батарей, можуть змінюватися через зміну вихідної потужності панелей. Метою даної роботи є покращення динамічних характеристик та зменшення пульсацій обертаючого моменту системи приводу асинхронного двигуна з живленням від Cuk перетворювача-інвертора. Новизна цієї роботи пропонує Cuk перетворювач, що чергується, між сонячним ФЕ джерелом постійного струму та інвертором. Мета. Забезпечення безперервності струму за допомогою Cuk перетворювача, що чергується, для приводу асинхронного двигуна і, у свою чергу, зменшення пульсації обертаючого моменту в асинхронному двигуні. Методологія. Представлений Cuk перетворювач, що чергується, який являє собою суміш Cuk перетворювачів, підключених паралельно один до одного між сонячними ФЕ батареями і системою приводу асинхронного двигуна. Оригінальність. Результати моделювання отримані для Cuk перетворювача і приводу асинхронного двигуна з живленням Cuk перетворювача, що чергується, за допомогою MATLAB. Розроблено апаратну частину цих же асинхронних двигунів. Практична цінність. Результати моделювання та апаратного забезпечення збігаються один з одним, і з результатів моделювання та апаратного забезпечення випливає, що система асинхронного двигуна з живленням від Cuk перетворювача-інвертора, що чергується, дає результати, які перевищують результати, ніж система приводу асинхронного двигуна з живленням від Cuk перетворювача

Subregional Hippocampal Thickness Abnormalities in Older Adults with a History of Heavy Cannabis Use.

Background and Aims: Legalization of cannabis (CB) for both medicinal and, in some states, recreational use, has given rise to increasing usage rates across the country. Of particular concern are indications that frequent CB use may be selectively harmful to the developing adolescent brain compared with adult-onset usage. However, the long-term effects of heavy, adolescent CB use on brain structure and cognitive performance in late-life remain unknown. A critical brain region is the hippocampus (HC), where there is a striking intersection between high concentrations of cannabinoid 1 (CB1) receptors and age-related pathology. Design: We investigated whether older adults (average age=66.6+7.2 years old) with a history of early life CB use show morphological differences in hippocampal subregions compared with older, nonusers. Methods: We performed high-resolution magnetic resonance imaging combined with computational techniques to assess cortical thickness of the medial temporal lobe, neuropsychological testing, and extensive drug use histories on 50 subjects (24 formerly heavy cannabis users [CB+ group] abstinent for an average of 28.7 years, 26 nonusers [CB- group]). We investigated group differences in hippocampal subregions, controlling for age, sex, and intelligence (as measured by the Wechsler Test of Adult Reading), years of education, and cigarette use. Results: The CB+ subjects exhibited thinner cortices in subfields cornu ammonis 1 [CA1; F(1,42)=9.96, p=0.0003], and CA2, 3, and the dentate gyrus [CA23DG; F(1,42)=23.17, p<0.0001], and in the entire HC averaged over all subregions [F(1,42)=8.49, p=0.006]. Conclusions: Negative effects of chronic adolescent CB use on hippocampal structure are maintained well into late life. Because hippocampal cortical loss underlies and exacerbates age-related cognitive decline, these findings have profound implications for aging adults with a history of early life usage. Clinical Trial Registration: ClinicalTrials.gov # NCT01874886

Physical Activity and Hippocampal Sub-Region Structure in Older Adults with Memory Complaints.

BackgroundPhysical activity (PA) plays a major role in maintaining cognition in older adults. PA has been shown to be correlated with total hippocampal volume, a memory-critical region within the medial temporal lobe (MTL). However, research on associations between PA and MTL sub-region integrity is limited.ObjectiveTo examine the relationship between PA, MTL thickness, and its sub-regions, and cognitive function in non-demented older adults with memory complaints.MethodsTwenty-nine subjects aged ≥60 years, with memory complaints were recruited for this cross-sectional study. PA was tracked for 7 days using accelerometers, and average number of steps/day determined. Subjects were categorized into two groups: those who walked ≤4000 steps/day (lower PA) and those with >4000 steps/day (higher PA). Subjects received neuropsychological testing and 3T MRI scans. Nonparametric ANCOVAs controlling for age examined differences between the two groups.ResultsTwenty-six subjects aged 72.7(8.1) years completed the study. The higher PA group (n = 13) had thicker fusiform gyrus (median difference = 0.11 mm, effect size (ES) = 1.43, p = 0.001) and parahippocampal cortex (median difference = 0.12 mm, ES = 0.93, p = 0.04) compared to the lower PA group. The higher PA group also exhibited superior performance in attention and information-processing speed (median difference = 0.90, ES = 1.61, p = 0.003) and executive functioning (median difference = 0.97, ES = 1.24, p = 0.05). Memory recall was not significantly different between the two groups.ConclusionOlder non-demented individuals complaining of memory loss who walked >4000 steps each day had thicker MTL sub-regions and better cognitive functioning than those who walked ≤4000 steps. Future studies should include longitudinal analyses and explore mechanisms mediating hippocampal related atrophy